Bussey-Saksida Mouse Touch Screen Chamber Package
Model 80614
- Add to the chamber, many options for different shaped walls and configurations, different floors, pellet or liquid reward, ambulatory I/R beams, I/R observation systems, and sound attenuation cubicles
- ABET II Touch software resides on the WhiskerServer Controller. One Controller can control up to 4 chambers
- Paradigms from Bussey’s lab [Cognitive Systems Neuroscience Laboratory, University of Cambridge, England] are available as pre-programmed ABET II Touch schedules
- Touch screen units are modified and optimized for use with rodents; all technology is research-validated and scientifically proven in Bussey's Lab
- Easy-Installation Kit keeps the wiring neat and tidy to get you up and running quickly and impress your regulatory inspector
- Beginner packages includes the starter chamber, trapezoidal walls, perforated floor, reward trough, touch screen and sound attenuating cubicle with slide out tray
Details
For more information about the ever expanding amount of published research using our Touch Screen Systems, visit the DOWNLOADS and SCIENCE sections! For more news about the system, check out our news page!
Look to Lafayette Instrument Company for a "Science above Hardware" approach not found from any other supplier. The fully validated chambers described below are supported by ready to run ABET II Touch Paradigms including images, and a Whisker ® Server-based Controller for up to four test chambers. Plus, we provide the ability for the user to write their own scheduling, with web-based training. ABET II Touch software gives you ease of use, programming power, data analysis, versatility, and flexibility.
- Not just a touch screen, everything about the Bussey-Saksida chamber is different
- Not just another square sheet metal box, the Bussey-Saksida chamber has a unique trapezoidal wall shape to focus the animal's attention and is made from machined parts that simply slot together. The chamber can also be configured to a modular square chamber with panels, levers, lights, and a range of other operator
- This equipment can run both autoshaping and a variety of operant tasks in the same chamber, with chamber configuration from autoshaping to one of the other proven paradigms in seconds Not just a touch screen, this is the ultimate modular chamber for high throughput. For example, do Visual Discrimination and Reversal in the morning and Five Choice Serial Reaction Time Task in the afternoon
- To enable such a high throughput, the chamber can be taken apart and reassembled in seconds for easy cleaning
- Get up and running quickly, with the Easy-Install Kit and buy proven tasks pre-programmed in ABET II Touch or get programming yourself quickly and easily with web-enabled online help from Campden Instruments and Lafayette Instrument Company
- Translational research: test rodents on tasks virtually identical to tasks used to test human populations
- The Bussey-Saksida Chambers and WhiskerServer ® originate from the department of Prof. Trevor Robbins, Experimental Psychology, University of Cambridge, England
TOUCH SCREEN PARADIGMS
Visit DOWNLOADS for videos of these tasks.
- Visual Discrimination and Reversal (VDR)
- Paired Associate Learning (PAL)
- Location Discrimination (LD)
- Visuospatial Conditional Learning (VCL)
- 5-choice Serial Reaction Time Task (5-CSRT)
- Trial-Unique Nonmatching-to-Location (TUNL) [rat only at this time]
- Autoshaping
- Extinction
VISUAL DISCRIMINATION AND REVERSAL TASK (VDR)
Age-related impairments in the R6/2 Huntington's disease mouse model
Morton, A., Skillings, E., Bussey, T. et al. Measuring cognitive deficits in disabled mice using an automated interactive touchscreen system. Nat Methods 3, 767 (2006). https://doi.org/10.1038/nmeth1006-767
PAIRED ASSOCIATE LEARNING TASK (PAL)
Intra-hippocampal infusions of MK-801 impair performance of the PAL task
But perhaps the most promising data from this task comes from our studies using donepezil, an acetylcholinesterase inhibitor that is a commonly prescribed drug for AD in the UK. Donepezil enhanced performance on PAL in a dose-dependent manner. This result shows that PAL is able to detect cognitive enhancements, as well as impairments.
LOCATION DISCRIMINATION TASK (LD)
McTighe, Stephanie M.a b; Mar, Adam C.a; Romberg, Carolaa; Bussey, Timothy J.a b; Saksida, Lisa M.a b A new touchscreen test of pattern separation: effect of hippocampal lesions, NeuroReport: June 17, 2009 - Volume 20 - Issue 9 - p 881-885
doi: 10.1097/WNR.0b013e32832c5eb2
Neurogenesis knock-down impairs pattern separation in the Location Discrimination Task
Clelland, Choi, Romberg, Clemenson, Fragniere, Tyers, Jessberger, Saksida, Barker, Gage & Bussey (2009) Science
Dorsal hippocampal lesions impair pattern separation in the Location Discrimination Task
McTighe, Stephanie M.a b; Mar, Adam C.a; Romberg, Carolaa; Bussey, Timothy J.a b; Saksida, Lisa M.a b A new touchscreen test of pattern separation: effect of hippocampal lesions, NeuroReport: June 17, 2009 - Volume 20 - Issue 9 - p 881-885
doi: 10.1097/WNR.0b013e32832c5eb2
AUTOSHAPING
Data from C57/Bl6 mice on the Autoshaping task. A stimulus (white rectangle) is shown on either the left or right of the screen for (usually) 10 seconds. Over trials the animal learns that the CS+ predicts reward and makes increasingly more responses to the CS+, and fewer responses to the CS-.
INCLUDES
- Touch Screen
- Chamber Base with non-shock perforated floors
- Trapezodal Walls
- Feeder Reward Area
- Liquid Pump Feeder
- Speaker
- House Light
- White Noise / Tone Generator
- SAC
Chamber shown with modular panel walls (Model 80614-3)
and corresponding reward trough (Model 80614-17).
Frequently Asked Questions
Specifications
ANIMAL WORKING AREA
- 46mm Wide at Feeder, 238mm Wide at Screen x 170mm Deep (241.4 Sq. cm or 37.5 Sq. in)
- Working Area is 230mm in Height
SOUND ATTENUATION CUBICLE (SAC)
- Attenuation: Approx. 35dB
- Weight: 33 kg (empty)
- External Dimensions: 565mm Wide x 545mm Tall x 532mm Deep
- Internal Dimensions: 505mm Wide x 485mm Tall x 532mm Deep
Science
LECTURE POSTER
Lecture Poster put together for Prof. Tim Bussey and the Distinguished Lecture Series located at Seoul National University on September 21, 2011.
PROFILE OF PROF. TIM BUSSEY
Prof. Tim Bussey's profile at the University of Cambridge.
TOUCHSCREENS AT WESTERN UNIVERSITY
Details on the usage of Bussey-Saksida Touchscreen Chambers at Western University.
TOUCHSCREEN TESTING AT UNIVERSITY OF CAMBRIDGE
Improving cognitive testing on animals to treat human disorders: Technology developed at the University of Cambridge is transforming the way cognitive tests are performed on animals, leading to more directed experiments and ultimately aiding development of new drugs to treat schizophrenia and other neurocognitive disorders.
START RUNNING AND WATCH YOUR BRAIN GROW, SAY SCIENTISTS
Guardian article on recent research indicating why regular exercise benefits brain cell growth.
PHYSICAL EXERCISE HELPS BRAINS GROWN, MOUSE STUDY FINDS
BBC Article on recent research indicating why regular exercise benefits memory.
RUNNING COULD HELP JOG MEMORY AND HELP BRAIN GROW, SAYS CAMBRIDGE STUDY
BBC Article on recent research indicating why regular exercise benefits brain power. Based on a Cambridge University study.
PAIRWISE DISCRIMINATION FOLLOWED BY REVERSAL IN C57BL6/J USING MOUSE TOUCH SCREEN OPERANT BOXES
Abstract and graph presented at British Association for Psychopharmacology (BAP) 2010.
CUSTOM SYSTEM INTEGRATIONS AVAILABLE ON REQUEST
Featured application plans to use touch screens with microdialysis for sampling in the extracellular space. As shown in the image our design enables the lines to the animals to be as short as possible (the entry point to the chamber are at the side at the connection panel with the cooling fan) and the carousel can be rolled in and out on a shelf.
Downloads
Product Brochures and Fliers
Product Manuals
Research Papers and Bibliographies
Videos
Accessories
Optional Accessories
ABET II Software for Touch Screens
Model 89505
Operant monitoring and control software for use with the Touch Screen modular hardware.
Precision Pellet Dispenser for 20mg Pellets
Model 80209A-20
Precision food dispenser with dispensing wheel that accommodates 20mg pellets.
Two-choice Paired/Visual Discrimination Reversal (PD) for Mice
Model 89540A
Adapted for mice, this reversal learning task requires inhibition of prepotent responses and is known to be dependent on the prefrontal cortex.
Paired-Associate Learning Task (PAL) for Mice
Model 89541A
Adapted for mice, this is a hippocampal task. In humans, this task has proved to be highly effective for the early detection of Alzheimer's disease.
Visuomotor Conditional Learning (VMCL) for Mice
Model 89542A
Adapted for mice, this is a habit or stimulus-response task in which the rodent learns a conditional rule.
5-choice Serial Reaction Time Task (5CSRT) for Mice
Model 89543A
Adapted for mice, this task is sensitive to cortical manipulations, especially those involving prefrontal cortex, and is highly dependent on cholinergic transmission.
Trial-unique Nonmatching-to-Location Task (TUNL) for Mice
Model 89545A
Adapted for mice, this is a working memory task. TUNL is a delayed nonmatching-to-place task that prevents the mediating strategies associated with the equivalent lever task.
Location Discrimination (LD) for Mice
Model 89546A
Adapted for mice, this is a spatial memory task with a reversal learning component. It is sensitive to hippocampal lesions and associated with glutamate receptor regulation and signaling.
Autoshaping (Auto) for Mice
Model 89544A
Adapted for mice, this task measures a Pavlovian response to the screen. This is a very rapidly administered test of simple classical conditioning that is dependent on a reward system centered on the ventral striatum.
Precision Liquid Feed Pump
Model 80204A
The rate of flow for the Precision Liquid Feed Pump is been calibrated to give precise delivery of liquids at delivery rates suitable for rewarding mouse, rat, and primate.
