5-choice Serial Reaction Time Task (5CSRT) for Mice

5-choice Serial Reaction Time Task (5CSRT) for Mice

Model 89543A


Adapted for mice, this task is sensitive to cortical manipulations, especially those involving prefrontal cortex, and is highly dependent on cholinergic transmission.



This task requires the rodent to respond to a brief visual stimulus presented randomly in one of 5 locations. This task in rodents is sensitive to cortical manipulations, especially those involving prefrontal cortex, and is highly dependent on cholinergic transmission.

Example Neural Systems Involved

  • Prefrontal Cortex
  • Basal Forebrain, Cholinergic (Accuracy)
  • Serotonin (Impulsivity)
  • Noradrenaline (Distraction)
  • Dopamine (Motivation)

Clinical Areas Showing Impairment

  • Alzheimer's
  • Depression
  • Huntington's
  • Schizophrenia,
  • ADHD,
  • OCD

Typical Training Times

  • 1-2 weeks to train to touch the screen and initiate the task
  • 6-24 sessions to train to criterion for task


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