Adapted for mice, this task is sensitive to cortical manipulations, especially those involving prefrontal cortex, and is highly dependent on cholinergic transmission.
This task requires the rodent to respond to a brief visual stimulus presented randomly in one of 5 locations. This task in rodents is sensitive to cortical manipulations, especially those involving prefrontal cortex, and is highly dependent on cholinergic transmission.
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Heath, C. J., O?Callaghan, C., Mason, S. L., Phillips, B. U., Saksida, L. M., Robbins, T. W., Barker, R. A., Bussey, T. J., & Sahakian, B. J. (2019). A Touchscreen Motivation Assessment Evaluated in Huntington?s Disease Patients and R6/1 Model Mice. Frontiers in Neurology, 10. - Abstract
Hambrecht-Wiedbusch, V. S., Latendresse, K. A., Avidan, M. S., Nelson, A. G., Phyle, M., Ajluni, R. E., & Mashour, G. A. (2019). General anesthesia does not have persistent effects on attention in rodents. Frontiers in Behavioral Neuroscience, 13. - Abstract
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Fitzpatrick, C. M., Maric, V. S., Bate, S. T., & Andreasen, J. T. (2018). Influence of intertrial interval on basal and drug-induced impulsive action in the 5-choice serial reaction time task. Neuroscience Letters. - Abstract
Kim, E. W., Phillips, B. U., Heath, C. J., Cho, S. Y., Kim, H., Sreedharan, J., Song, H. T., Lee, J. E., Bussey, T. J., Kim, C. H., Kim, E., & Saksida, L. M. (2017). Optimizing reproducibility of operant testing through reinforcer standardization: Identification of key nutritional constituents determining reward strength in touchscreens. Molecular Brain, 10(1). - Abstract
Second Generation Bussey Chamber developed for mice with Intelli-interface supports up to 20 chambers on one PC. On the strength of 10 years of feedback and development, the system is even more flexible and with more features.
