The rodents are required to discriminate between two white squares on the screen. Responses to squares on one side of the screen will be rewarded, while responses on the other side of the screen will be punished with a time out period. The distance between the two squares is varied from trial to trial. Animals with lesions in the dorsal hippocampus were impaired when the locations were close together, but not when they were far apart. Once 7 out of 8 trials are responded to correctly, the correct side is reversed, adding a reversal learning component. It is sensitive to hippocampal lesions and associated with glutamate receptor regulation and signalling.
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Yoo, S., Stremlau, M., Pinto, A., Woo, H., van Praag, H., & Curtis, O. (2021). Effects of combined anti-hypertensive and statin treatment on memory, fear extinction, adult neurogenesis, and angiogenesis in adult and middle-aged mice. Cells, 10(7), 1778. - Abstract
Trammell, T. S., Henderson, N. L., Madkour, H. S., Stanwood, G. D., & Graham, D. L. (2020). GLP-1R activation alters performance in cognitive tasks in a sex-dependent manner. Neurological Sciences. - Abstract