Location Discrimination (LD) for Mice

Details

The rodents are required to discriminate between two white squares on the screen. Responses to squares on one side of the screen will be rewarded, while responses on the other side of the screen will be punished with a time out period. The distance between the two squares is varied from trial to trial. Animals with lesions in the dorsal hippocampus were impaired when the locations were close together, but not when they were far apart. Once 7 out of 8 trials are responded to correctly, the correct side is reversed, adding a reversal learning component. It is sensitive to hippocampal lesions and associated with glutamate receptor regulation and signalling.

Example Neural Systems Involved

• Hippocampus
• Neurogenesis

Clinical Areas Showing Impairment

• Schizophrenia
• Alzheimers's

Cognitive Functions Covered

• Learning and Memory
• Location Discrimination / Pattern Separation

Typical Training Times (depends on strain and age)

• 1-2 weeks to train to touch the screen and initiate the task
• 10-20 sessions

Science

Palmer, D., Dumont, J. R., Dexter, T. D., Prado, M. A. M., Finger, E., Bussey, T. J., & Saksida, L. M. (2021). Touchscreen cognitive testing: Cross-species translation and co-clinical trials in neurodegenerative and neuropsychiatric disease. In Neurobiology of Learning and Memory (Vol. 182, p. 107443). - Abstract

Yoo, S., Stremlau, M., Pinto, A., Woo, H., van Praag, H., & Curtis, O. (2021). Effects of combined anti-hypertensive and statin treatment on memory, fear extinction, adult neurogenesis, and angiogenesis in adult and middle-aged mice. Cells, 10(7), 1778. - Abstract

Trammell, T. S., Henderson, N. L., Madkour, H. S., Stanwood, G. D., & Graham, D. L. (2020). GLP-1R activation alters performance in cognitive tasks in a sex-dependent manner. Neurological Sciences. - Abstract

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