Probabilistic Reversal Learning (PRL) for Mice

Details

Designed to measure sensitivity to valence (i.e. positive and negative) feedback information, PRL is sensitive to serotonergic manipulations, suggesting this test may be used to study depression-relevant behaviour in rodents

Example Neural Systems Involved

• Serotonin

Clinical Areas Showing Impairment

• Depression

Cognitive Functions Covered

• Emotional cognition and responding to reinforcement

Typical Training Times (depends on strain and age)

• 1-2 weeks to train to touch the screen and initiate the task
• ~17 sessions training to the task

Science

Wilkinson, M. P., Grogan, J. P., Mellor, J. R., & Robinson, E. S. J. (2020). Comparison of conventional and rapid-acting antidepressants in a rodent probabilistic reversal learning task. Brain and Neuroscience Advances, 4, 239821282090717. - Abstract

Phillips, B. U., Dewan, S., Nilsson, S. R. O., Robbins, T. W., Heath, C. J., Saksida, L. M., Bussey, T. J., & Alsi?, J. (2018). Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice. Psychopharmacology, 235(7), 2101?2111. - Abstract

Accessories

Required Accessories

Second Generation Bussey-Saksida Touch Screen Chamber for Mice
Model 80614A

Second Generation Bussey Chamber developed for mice with Intelli-interface supports up to 20 chambers on one PC. On the strength of 10 years of feedback and development, the system is even more flexible and with more features.

Details