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Campden Vibratomes – Precision Vibrating Microtomes

Campden Instruments manufactures vibratomes (also known as vibrating microtomes or brain slice microtomes) used worldwide for live and fixed tissue sectioning. Our 5100mz, 5100mz-Plus, and 9000SMZ vibratomes are trusted by leading neuroscience, histology, and organotypic culture labs to produce reproducible brain slice and tissue sections.

Our Vibrating Microtomes

5100mz Vibratome

Compact, user-friendly model ideal for entry-level use and fixed tissue sectioning.

  • Semi-automatic
  • Basic electrophysiology
  • 50 - 80 Hz blade frequency
  • Z-axis deflection 5 - 8µm
  • Live or fixed tissue
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5100mz-Plus Vibratome

5100mz-Plus Vibratome

Enhanced for live tissue slicing, offering ultra-low vibration and precision control.

  • Includes Opti-Cal for Z-axis deflection measurement
  • Z-axis deflection 0.0µm (±2.0µm)
  • 50 - 80 Hz blade frequency
  • Live or fixed tissue
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9000smz Vibratome

9000SMZ Vibratome

Top-tier automation and accuracy for high-throughput slicing.

  • Touchscreen control
  • Full automation
  • Z-axis deflection 0.0µm (±0.1µm)
  • 20 - 120 Hz blade frequency
  • 5 YEAR WARRANTY
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Vibratome Applications

Our vibrating microtomes are used in:

 

Vibratome Cortex Slice
40x IR-DIC Entorhinal Cortex Slice from 9 month-old Rat. Slicing Parameters:
Blade: Ceramic;
Blade Frequency: 50Hz;
Blade Amplitude: 1mm;
Advance Speed: 0.05 mm/s.

Why Choose Campden Instruments?

✔ UK-Engineered Precision

All vibratomes (vibrating microtomes) are manufactured in our quality-controlled UK facility.

✔ Near-Zero Blade Deflection

Maintain soft tissue integrity with unmatched Z-axis control.

✔ Research Proven

Vibrating microtomes featured in 4000+ peer-reviewed studies across life sciences. Download Bibliography ➡

Vibrating Microtome Global Support

Expert advice, training and servicing provided to the 500+ labs in 45 countries.

What Our Customers Say

Our lab has two [Campden] vibratomes used to generate precision-cut lung slices from both animal and human tissue as well as precision-cut slices from other organs. We are particular happy with the consistency in slice generation, flexibility and range of slice thickness, ease of use, and last but not least the customer support offered by Campden Instruments

John Stegmayr, PhD, Lund University

Our laboratory uses both animal and human tissue in acute and organotypic culture brain slice experiments. We have two [Campden] vibratomes in daily use which form the backbone of our slice preparations – the reliability and repeatability provided by the slicer’s Z-axis stability and calibration mechanism means that our preparations get off to the best possible start. The [Campden] vibratome produces the highest quality brain slices of any vibratome I have used, allowing us to generate in vivo-like oscillations in slice preparations. On top of this the service and support from Campden has been second to none.

Stuart Greenhill, PhD, Aston University

Trusted by Leading Universities Worldwide

Our vibrating microtomes are used in over 500 laboratories worldwide.

Cambridge University
University of Glasgow
MIT
Oxford University
UCL
Cambridge University
University of Glasgow
MIT
Oxford University
UCL

Download Our Vibratome Brochures

Access detailed brochures for each Campden Instruments vibrating microtome, including specifications, features, and applications.

5100mz Vibratome

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5100mz-Plus Vibratome

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9000SMZ Vibratome

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Frequently Asked Questions

What is a vibratome (vibrating microtome)?
A vibratome—also called a vibrating microtome or brain slice microtome—is a precision instrument that uses a vibrating blade to section live or fixed tissue with minimal deformation, preserving cellular architecture for electrophysiology, imaging and histology.
Which Campden vibratome model is best for my application?
5100mz: versatile for routine sections of fixed or live tissue.
5100mz-Plus: enhanced stability and control for demanding live tissue brain slices.
9000 SMZ: premium stability and ultra-low Z-axis deflection for advanced live tissue work and long experiments.
What tissue types can I section with a vibratome?
Common applications include brain slice preparation (hippocampus, cortex), spinal cord, cardiac, lung, liver, kidney and plant tissue. Many labs also use Campden vibratomes for organotypic cultures and acute slice electrophysiology.
What slice thickness range can I achieve?
Typical ranges are ~30–1000 µm depending on tissue and protocol. Researchers often use 250–400 µm for live brain slices and thinner sections for histology or imaging. Final results depend on sample prep, blade, speed and amplitude settings.
Which blades are recommended?
High-quality stainless steel or ceramic blades are commonly used. Choice depends on tissue rigidity and target thickness. Use fresh, undamaged blades and ensure proper clamping to minimize chatter and Z-axis deflection.
How do I optimize settings for live brain slices?
Start with low advance speed, moderate vibration amplitude, chilled oxygenated cutting solution and secure tissue support. Adjust incrementally while monitoring slice quality. The 5100mz-Plus and 9000 SMZ provide fine control for this use case.
What maintenance is required?
Clean the tray, specimen holder and blade clamps after each session; check fasteners; replace worn consumables; and follow routine calibration checks. Regular care improves reproducibility and extends instrument life.
Do you provide training and technical support?
Yes—Campden Instruments offers setup guidance, best-practice resources and responsive technical support. Contact our team for application advice and troubleshooting.
What are the lead times and shipping options?
Lead times vary by model and region. Campden Instruments ships globally through authorized channels. Request a quote for current availability, shipping options and documentation.
Can I get pricing or a formal quotation?
Yes—use the “Contact our Experts” button on this page to request a formal quotation for the 5100mz, 5100mz-Plus or 9000SMZ. Include your application details for tailored guidance.
Are Campden vibratomes CE marked?
Campden Instruments equipment is CE compliant.
Where can I download brochures and manuals?
Brochures for each model are available in the “Download Brochures” section of this page. For manuals, contact our support team.

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