In extracellular recording usually very small potentials in the µV range are measured. This requires high amplification and often also filtering.
npi’s range of extracellular amplifiers meet these requirements. They are available as desktop instruments, in a 19” rackmount cabinet or as module for the EPMS modular system. All npi extracellular amplifiers have high pass and low pass filter and gain up to 10000. They allow DC measurements and AC recordings in which offsets are cancelled automatically. Audio monitors and electrode resistance meters are available as well. The use of external power supplies and high quality electronics ensure low-noise recording of small signals.
Models include:
Most systems are equipped with a small headstage with high impedance differential inputs to suppress noise and other distortions.
The EXT-02F has two differential inputs with high input resistance via BNC connectors or optionally with headstages. The output voltage signal is available AC or DC with variable gain (up to 10k), and can be filtered. The system is housed in a desktop metal case with an external power supply.
Two LEDs indicate whether the amplifier is running out of its linear range and an analog balance monitor makes the control of offsets easy. Furthermore, an audio monitor allows acoustic control of the recorded signal. The EXT-02F is also available as one-channel version.
The amplifer is suitable for single unit recording as well as for EEG and ECG recordings.
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HEADSTAGES (optional) |
Operating voltage ±12 V; Size (approx.): 65x25x25mm |
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AC/DC OUTPUT |
filtered and amplified |
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DIFFERENTIAL INPUT |
BNC / SMB connector with headstage or BNC connectors |
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LOW PASS FILTER |
30, 100, 500, 700, 900, 1.3k, 1.5k, 1.7k, 3k, 10k, 20k Hz |
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HIGH PASS FILTER |
OFF, 3, 30, 100, 300, 400, 500, 600, 800, 1k, 3k, 10k Hz |
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AUDIO MONITOR |
PITCH or NOISE, DC or AC |
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GAIN |
10, 20, 50, 100, 200, 500, 1k, 2k, 5k, 10k |
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OFFSET COMPENSATION |
Potentiometer with 2 ranges: ±0.1 V or ±1 V |
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MONITORS |
Impedance: 250 Ohms |
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ANALOG BALANCE MONITOR |
ca. ±30 mV |
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EXTERNAL POWER SUPPLY |
AC output; 12-18V, 1 A |
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DIMENSIONS |
245 x 200 x 90 mm |
Kadakia, N., Demir, M., Michaelis, B. T., DeAngelis, B. D., Reidenbach, M. A., Clark, D. A., & Emonet, T. (2022). Odour motion sensing enhances navigation of complex plumes. Nature, 611(7937), 754–761.
https://doi.org/10.1038/s41586-022-05423-4
Tantillo, E., Scalera, M., De Santis, E., Meneghetti, N., Cerri, C., Menicagli, M., Mazzoni, A., Costa, M., Mazzanti, C. M., Vannini, E., & Caleo, M. (2023). Molecular changes underlying decay of sensory responses and enhanced seizure propensity in peritumoral neurons. Neuro-Oncology. https://doi.org/10.1093/neuonc/noad035
Juarez, E. V., Srivastava, I., & Lindskog, M. (2022). Impaired glutamate reuptake induces synaptic mistuning in rat hippocampal slices, that can be counteracted by ketamine. BioRxiv, 2022.01.25.477658. https://doi.org/10.1101/2022.01.25.477658
