LumiCycle In Vivo

Details

LumiCycle In Vivo is designed to record PER-LUC light emissions from awake behaving animals placed in a standard mouse cage and infused with luciferin analogs.

For over a decade, it has been possible to record PER-LUC light emission from isolated tissues and cells. As methods and signals improve, it is now possible to record light emission from intact, behaving animals, opening up a wide range of experiments on the interactions among the clocks in different organs operating in their natural environment. LumiCycle In Vivo is a simple, robust apparatus for recording luminescence from intact animals, while simultaneously recording activity, monitoring light, temperature, and humidity within the chamber, and controlling the lights in infinitely programmable skeleton schedules.

• Two PMTs for even sensitivity across the cage area.
• Red-shifted PMT sensitivity to accommodate the absorption of green photons by the intervening tissues.
• Activity input for recording through a running wheel or IR motion sensor.
• Programmable LED lights in each chamber for creating skeleton light schedules.
• Light levels, temperature and humidity recorded continuously for animal care and use monitoring.
• High-capacity internal fan for 15 air changes per hour.
• Up to 8 units can be run on one computer. Recording on each unit can be started and stopped independently, and each can be given its own light schedule.
• Data can be viewed and analyzed in the LumiCycle Analysis or ClockLab Analysis programs.

Specifications

Maximum Cage Dimensions:

• Length: 13.25″ (33 cm)
• Width: 8.5″ (21 cm)
• Height: 7.5″ (19 cm)

# of PMTs: 2

PMT Dark counts:

• < 100/sec @ room temperature.
• Minute-to-minute standard deviation in dark counts less than 2/sec.

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