Based on the Iowa Gambling Task, the rodent chooses from four illuminated windows. A touch in any of the windows will result in either a Win (food reward is delivered) or a Loss (timeout period with no reward). Each window is associated with a different amount of reward. The larger the associated reward, the lower the probability of receiving a Win and the longer the timeout if the trial results in a Loss. The subject must learn to avoid the high-risk, high-reward options in order to maximize earnings. The test is sensitive to serotonergic and dopaminergic agents.
Openshaw, R. L., Pratt, J. A., & Morris, B. J. (2022). The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task. Disease Models & Mechanisms, 15(3). - Abstract
Humby, T., Smith, G. E., Small, R., Davies, W., Carter, J., Bentley, C. A., Winstanley, C. A., Rogers, R. D., & Wilkinson, L. S. (2020). Effects of 5-HT 2C, 5-HT 1A receptor challenges and modafinil on the initiation and persistence of gambling behaviours. Psychopharmacology, 237(6), 1745–1756. - Abstract
Cho, B. R., Kwak, M. J., Kim, W. Y., & Kim, J. H. (2018). Impulsive action and impulsive choice are differentially expressed in rats depending on the age at exposure to a gambling task. Frontiers in Psychiatry, 9(OCT), 503. - Abstract
Coba MP, Komiyama NH, Nithianantharajah J, et al. (2012) TNiK is required for postsynaptic and nuclear signalling pathways and cognitive function. J Neurosci.; 32(40):13987-13999.
The Second Generation Bussey Chambers with Intelli-interface supports up to 20 chambers on one PC. On the strength of 10 years of feedback and development, the system is even more flexible and with more features.
