The task involves learning that one of two shapes displayed simultaneously on the screen is correct. Touching the correct stimuli (S+) will be rewarded with food. Touching the incorrect stimuli (S-) will be punished with a timeout. Once the task has been learned, the stimuli are reversed so that the S+ stimuli now becomes the S- stimuli and vice versa. This reversal learning requires inhibition of prepotent responses and is known to be dependent on the prefrontal cortex.
Tethered Rat performing the Pairwise/Visual Discrimination Task (PD), in a Bussey Touch screen chamber for Electrophysiology recording.
Grey Mouse Lemur performing the Pairwise/Visual Discrimination Task (PD) An entrance hole has been made in the side wall to allow the Grey Mouse Lemur to be placed in the chamber without handling.
Tree Shrew performing the training phase for the Pairwise/Visual Discrimination Task (PD). Another example of the multi species use of these chambers.
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DeBrosse, A. C., Wheeler, A. M., Barrow, J. C., & Carr, G. V. (2020). Inhibition of Catechol-O-methyltransferase Does Not Alter Effort-Related Choice Behavior in a Fixed Ratio/Concurrent Chow Task in Male Mice. Frontiers in Behavioral Neuroscience, 14. - Abstract
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Radke, A. K., Zweifel, L. S., & Holmes, A. (2019). NMDA receptor deletion on dopamine neurons disrupts visual discrimination and reversal learning. Neuroscience Letters, 699, 109–114. - Abstract
Phillips, B. U., Dewan, S., Nilsson, S. R. O., Robbins, T. W., Heath, C. J., Saksida, L. M., Bussey, T. J., & Alsiö, J. (2018). Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice. Psychopharmacology, 235(7), 2101–2111. - Abstract
The Second Generation Bussey Chambers with Intelli-interface supports up to 20 chambers on one PC. On the strength of 10 years of feedback and development, the system is even more flexible and with more features.
Adapted for mice, this reversal learning task requires inhibition of prepotent responses and is known to be dependent on the prefrontal cortex.
