5-Choice Continuous Performance Test (5C-CPT) for Rats
 

5-Choice Continuous Performance Test (5C-CPT) for Rats

Model 89548A-R


  • A test of attention and behavioral inhibition
  • All training paradigms and advice included
 

Details

Like the 5-choice serial reaction task, this task requires the rodent to respond to a brief visual stimulus presented randomly in one of 5 locations. In addition. some trials present visual stimuli in all five locations together and for these trials the subject must learn to withhold a response. This go/no-go task measures both attentional and inhibitory systems within a single task paradigm, enabling the assessment of vigilance.

Example Neural Systems Involved

  • Dopamine
  • Serotonin
  • Cholinergic
  • Parietal
  • Muscarinic

Clinical Areas Showing Impairment

  • Alzheimer's
  • Schizophrenia
  • ADHD
  • OCD

Cognitive Functions Covered

  • Impulsivity
  • Attention
  • Cognitive Flexibility and response inhibition

Typical Training Times (depends on strain and age)

  • ~ 30 sessions

Science

Cavanagh, J. F., Gregg, D., Light, G. A., Olguin, S. L., Sharp, R. F., Bismark, A. W., Bhakta, S. G., Swerdlow, N. R., Brigman, J. L., & Young, J. W. (2021). Electrophysiological biomarkers of behavioral dimensions from cross-species paradigms. Translational Psychiatry 2021 11:1, 11(1), 1-11. - Abstract

Braeckman, K., Descamps, B., Vanhove, C., & Caeyenberghs, K. (2019). Exploratory relationships between cognitive improvements and training induced plasticity in hippocampus and cingulum in a rat model of mild traumatic brain injury: a diffusion MRI study. Brain Imaging and Behavior. - Abstract

Arulsamy, A., Corrigan, F., & Collins-Praino, L. E. (2019). Age, but not severity of injury, mediates decline in executive function: Validation of the rodent touchscreen paradigm for preclinical models of traumatic brain injury. Behavioural Brain Research, 368. - Abstract

Braeckman, K., Descamps, B., Caeyenberghs, K., & Vanhove, C. (2018). Longitudinal DTI changes following cognitive training therapy in a mild traumatic brain injury rat model. Frontiers in Neuroscience, 12. - Abstract

Accessories

Required Accessories

Second Generation Bussey-Saksida Touch Screen Chamber for Rats
Second Generation Bussey-Saksida Touch Screen Chamber for Rats
Model 80604A

The Second Generation Bussey Chambers with Intelli-interface supports up to 20 chambers on one PC. On the strength of 10 years of feedback and development, the system is even more flexible and with more features.

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